This study explored the effectiveness of the Fitterfly Weight loss digital therapeutics program among 135 individuals in overweight and obese categories. Reduction in weight, body mass index (BMI), and waist circumference was observed by 4.00 kg, 1.50 kg/m2, and 6.00 cm respectively. At the end of the program, median reduction in intake of calories, carbohydrates, proteins, and fats by 427.00 kcal, 56.00 gm, 6.40 gm, and 18.40 gm was observed respectively. Thus, Fitterfly weight loss program can help in clinically significant weight loss among individual in obese or overweight category.